Tal Effectors

Transcription activator-like effector nuclease

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting.

TALENs are essential new instruments for genome engineering. Fusions of transcription activator-like (TAL) effectors of plant pathogenic Xanthomonas spp. to the FokI nuclease, TALENs bind and cleave DNA in pairs. Binding specificity is set by customizable arrays of polymorphic amino acid repeats within the TAL effectors. We current a way and reagents for effectively assembling TALEN constructs with custom repeat...