DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.

DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.

DNA-dependent protein kinase (DNA-PK), which is concerned in DNA double-strand break restore and V(D)J recombination, is comprised of a DNA-targeting element termed Ku and an roughly 465-kD catalytic subunit, DNA-PKcs. Although DNA-PK phosphorylates proteins in the presence of DSBs or different discontinuities in the DNA double helix in vitro, the risk exists that additionally it is activated in different circumstances via its …

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