Wednesday, 19 June, 2024

Tal Effectors

Transcription activator-like effector nuclease

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  • daTALbase: a database for genomic and transcriptomic data related to TAL effectors.
daTALbase: a database for genomic and transcriptomic data related to TAL effectors.
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daTALbase: a database for genomic and transcriptomic data related to TAL effectors.

Transcription activator-like effectors (TALEs) are proteins discovered within the genus Xanthomonas of phytopathogenic micro organism. These proteins enter the nucleus of cells within the host plant and can induce the expression of susceptibility genes (S genes), triggering illness. TALEs bind the promoter area of S genes following a particular code, which permits the prediction of binding websites based mostly on TALEs amino acid sequences.
New candidate S genes can then be found by discovering the intersection between genes induced within the presence of TALEs and genes containing predicted effector binding components. By contrasting differential expression data and binding website predictions throughout totally different datasets, patterns of TALE diversification or convergence could also be unveiled, however this requires the seamless integration of various genomic and transcriptomic data.
With this in thoughts, we current daTALbase, a curated relational database that integrates TALE-related data together with bacterial TALE sequences, plant promoter sequences, predicted TALE binding websites, transcriptomic data of host crops in response to TALE-harboring micro organism, and different related data. The database might be explored to uncover new candidate S genes in addition to to research variation in TALE repertories and their corresponding targets. The first model of the database right here offered consists of data for Oryza sp.-Xanthomonas pv. oryzae interactions. Future variations of the database will incorporate info for different pathosystems involving TALEs.

The impact of accelerating numbers of repeats on TAL effector DNA binding specificity.

Transcription activator-like effectors (TALEs) acknowledge their DNA targets by way of tandem repeats, every specifying a single nucleotide base in a one-to-one sequential association. Due to this modularity and their capacity to bind lengthy DNA sequences with excessive specificity, TALEs have been utilized in many functions. Contributions of particular person repeat-nucleotide associations to affinity and specificity have been characterised.
Here, utilizing in vitro binding assays, we examined the connection between the variety of repeats in a TALE and its affinity, for each goal and non-target DNA. Each extra repeat offers additional binding power for the goal DNA, with the acquire decaying exponentially such that binding power saturates. Affinity for non-target DNA additionally will increase non-linearly with the variety of repeats, however with a slower decay of acquire.
The distinction between the impact of size on affinity for goal versus non-target DNA manifests in specificity growing then diminishing with growing TALE size, peaking between 15 and 19 repeats. Modeling throughout totally different hypothetical saturation ranges and charges of acquire decay, reflecting totally different repeat compositions, yielded a comparable vary of specificity optima. This vary encompasses the imply and median size of native TALEs, suggesting that these proteins as a group have developed for most specificity.

Targeted promoter enhancing for rice resistance to Xanthomonas oryzae pv. oryzae reveals differential actions for SWEET14-inducing TAL effectors.

As a key virulence technique to trigger bacterial leaf blight, Xanthomonas oryzae pv. oryzae (Xoo) injects into the plant cell DNA-binding proteins referred to as transcription activator-like effectors (TALEs) that bind to effector-binding components (EBEs) in a sequence-specific method, leading to host gene induction. TALEs AvrXa7, PthXo3, TalC and Tal5, present in geographically distant Xoo strains, all goal OsSWEET14, thus thought of as a pivotal TALE goal performing as main susceptibility issue throughout rice-Xoo interactions.
Here, we report the technology of an allele library of the OsSWEET14 promoter via steady expression of TALE-nuclease (TALEN) constructs in rice. The susceptibility stage of traces carrying mutations in AvrXa7, Tal5 or TalC EBEs was assessed. Plants edited in AvrXa7 or Tal5 EBEs have been resistant to bacterial strains counting on the corresponding TALE. Surprisingly, though indels inside TalC EBE prevented OsSWEET14 induction in response to BAI3 wild-type micro organism counting on TalC, lack of TalC responsiveness failed to confer resistance to this pressure.
The TalC EBE mutant line was, nevertheless, resistant to a pressure expressing a synthetic SWEET14-inducing TALE whose EBE was additionally edited on this line. This work gives the primary set of alleles edited in TalC EBE and uncovers a distinct, broader vary of actions for TalC in contrast to AvrXa7 or Tal5. We suggest the existence of extra targets for TalC past SWEET14, suggesting that TALE-mediated plant susceptibility might consequence from induction of a number of, genetically redundant, host susceptibility genes by a single effector.

Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition.

DNA recognition by transcription activator-like effector (TALE) proteins is mediated by tandem repeats that specify nucleotides via repeat-variable diresidues. These repeat-variable diresidues type direct and sequence-specific contacts to DNA bases; therefore, TALE-DNA interplay is delicate to DNA chemical modifications. Here we conduct a thorough investigation, overlaying all theoretical repeat-variable diresidue combos, for their recognition capabilities for 5-methylcytosine and 5-hydroxymethylcytosine, two vital epigenetic markers in greater eukaryotes.
daTALbase: a database for genomic and transcriptomic data related to TAL effectors.
We determine each particular and degenerate repeat-variable diresidues for 5-methylcytosine and 5-hydroxymethylcytosine. Utilizing these novel repeat-variable diresidues, we obtain methylation-dependent gene activation and genome enhancing in vivo; we additionally report base-resolution detection of 5hmC in an in vitro assay.

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Description: Rabbit polyclonal NEIL3 antibody

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Description: A polyclonal antibody against NEIL3. Recognizes NEIL3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

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Description: A polyclonal antibody against NEIL3. Recognizes NEIL3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

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CSB-PA065468-100ul Cusabio 100ul 379.2 EUR
Description: A polyclonal antibody against NEIL3. Recognizes NEIL3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

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Description: NEIL3 Rabbit Polyclonal Antibody

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Description: NEIL3 Rabbit Polyclonal Antibody

anti- NEIL3 antibody

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Description: Antibody raised against NEIL3

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NEIL3 Polyclonal Antibody

ABP51918-003ml Abbkine 0.03ml 189.6 EUR
Description: A polyclonal antibody for detection of NEIL3 from Human, Mouse. This NEIL3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NEIL3 at AA range: 460-540

NEIL3 Polyclonal Antibody

ABP51918-01ml Abbkine 0.1ml 346.8 EUR
Description: A polyclonal antibody for detection of NEIL3 from Human, Mouse. This NEIL3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NEIL3 at AA range: 460-540

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ABP51918-02ml Abbkine 0.2ml 496.8 EUR
Description: A polyclonal antibody for detection of NEIL3 from Human, Mouse. This NEIL3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NEIL3 at AA range: 460-540

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E041212 EnoGene 100μg/100μl 255 EUR
Description: Available in various conjugation types.

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E96819 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

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Description: Available in various conjugation types.

NEIL3 Polyclonal Antibody

BT-AP05878-100ul Jiaxing Korain Biotech Ltd (BT Labs) 100ul Ask for price
Description: NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

NEIL3 Polyclonal Antibody

BT-AP05878-20ul Jiaxing Korain Biotech Ltd (BT Labs) 20ul Ask for price
Description: NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

NEIL3 Polyclonal Antibody

BT-AP05878-50ul Jiaxing Korain Biotech Ltd (BT Labs) 50ul Ask for price
Description: NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

NEIL3 Polyclonal Antibody

E44H05440 EnoGene 100ul 255 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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Rabbit anti-Homo sapiens (Human) NEIL3 Polyclonal Antibody

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NEIL3 Antibody - middle region

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NEIL3 Antibody - middle region

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OACD05928-1ML - NEIL3 Antibody

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OACD05928-100UL - NEIL3 Antibody

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NEIL3 siRNA (Human)

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NEIL3 siRNA (Human)

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Recombinant Human NEIL3

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NEIL3 Rabbit Polyclonal Antibody

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Description: A Rabbit Polyclonal antibody against NEIL3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

NEIL3 Rabbit Polyclonal Antibody

ES2917-50ul ELK Biotech 50ul 74 EUR
Description: A Rabbit Polyclonal antibody against NEIL3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Mouse monoclonal antibody Anti-Human NEIL3

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Mouse monoclonal antibody Anti-Human NEIL3

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Human NEIL3 ELISA KIT

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NEIL3 Antibody(Center) Blocking peptide

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NEIL3 Polyclonal Conjugated Antibody

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NEIL3 Polyclonal Conjugated Antibody

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Human NEIL3 shRNA Plasmid

20-abx960591 Abbexa
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Human NEIL3 Protein Lysate

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Anti-NEI3/NEIL3 Antibody (aa491-540)

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Anti-NEI3/NEIL3 Antibody (aa491-540)

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NEIL3 (untagged)-Human nei endonuclease VIII-like 3 (E. coli) (NEIL3)

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NEIL3(Center) Rabbit Polyclonal Antibody

E10G34728 EnoGene 100 μl 275 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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ARP75647_P050-25UL - NEIL3 Antibody - middle region

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NEIL3 (GFP-tagged) - Human nei endonuclease VIII-like 3 (E. coli) (NEIL3)

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Human NEIL3 knockout cell line

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Description: Human NEIL3 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

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Description: Human NEIL3 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human NEIL3 Protein Lysate 20ug

IHUNEIL3PLLY20UG Innovative research each 213 EUR
Description: Human NEIL3 Protein Lysate 20ug

NEIL3 ORF Vector (Human) (pORF)

ORF026030 ABM 1.0 ug DNA 486 EUR

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A05497-3 BosterBio 100ul 380 EUR
Description: Boster Bio Anti-Endonuclease 8-like 3 NEIL3 Antibody catalog # A05497-3. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.

NEIL3 ELISA Kit (Human) (OKEH05107)

OKEH05107 Aviva Systems Biology 96 Wells 872.4 EUR
Description: Description of target: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.417 ng/mL

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NEI3 (NEIL3) (NM_018248) Human Over-expression Lysate

LS055247 BosterBio 100ug 628 EUR
Description: Transient overexpression lysate of nei endonuclease VIII-like 3 (E. coli) (NEIL3)

Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

20-abx129922 Abbexa
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  • 100 ug
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  • 1 mg
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Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

20-abx177722 Abbexa
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  • 1 mg
  • 200 ug

Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

20-abx325929 Abbexa
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  • 100 ug
  • 50 ug

Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

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Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

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Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

abx129922-200l Abbexa 200 µl 375 EUR

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Nei Endonuclease VIII Like Protein 3 (NEIL3) Antibody

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NEI3 (NEIL3) (164-177) rabbit polyclonal antibody, Aff - Purified

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OKEH05107-96W - NEIL3 ELISA Kit (Human)

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Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

20-abx008114 Abbexa
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  • 100 ul
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  • 30 ul

Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

abx030990-400ul Abbexa 400 ul 627.6 EUR

Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

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Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

20-abx014459 Abbexa
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  • 100 ug
  • 10 ug
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Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

abx235649-100ug Abbexa 100 ug 661.2 EUR

Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

abx030990-400l Abbexa 400 µl 518.75 EUR

Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

abx235649-100g Abbexa 100 µg 350 EUR

Nei Endonuclease VIII-Like 3 (E. Coli) (NEIL3) Antibody

abx014459-100g Abbexa 100 µg 43.75 EUR

NEIL3 sgRNA CRISPR Lentivector set (Human)

K1416101 ABM 3 x 1.0 ug 406.8 EUR

NEIL3 Protein Vector (Human) (pPM-C-HA)

PV104120 ABM 500 ng 662.4 EUR

NEIL3 Protein Vector (Human) (pPB-C-His)

PV104118 ABM 500 ng 662.4 EUR

NEIL3 Protein Vector (Human) (pPB-N-His)

PV104119 ABM 500 ng 662.4 EUR

NEIL3 Protein Vector (Human) (pPM-C-His)

PV104121 ABM 500 ng 662.4 EUR

Human NEIL3 Over-expressing Stable Cell Line

ABC-X2020 AcceGen 1 vial Ask for price
Description: Gentaur can provide custom lentiviral constructs expressing any genes of interest as long as it is less than about 3 kb. Lentiviral technology enables us to efficiently generate stable expression lines which are then selected for moderate or high expressers, depending on the experimental requirements. If you are interested in specific lentiviral DNA constructs or have further questions, please contact us to discuss the details. NEIL3 nei endonuclease VIII-like 3 (E. coli) [ Homo sapiens ] http://www.ncbi.nlm.nih.gov/gene/55247

NEIL3 siRNA

20-abx925706 Abbexa
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  • 15 nmol
  • 30 nmol

NEIL3 siRNA

20-abx925707 Abbexa
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Rabbit anti-Mus musculus (Mouse) NEIL3 Polyclonal Antibody

MBS9001922-INQUIRE MyBiosource INQUIRE Ask for price

NEIL3 sgRNA CRISPR Lentivector (Human) (Target 1)

K1416102 ABM 1.0 ug DNA 184.8 EUR

NEIL3 sgRNA CRISPR Lentivector (Human) (Target 2)

K1416103 ABM 1.0 ug DNA 184.8 EUR

NEIL3 sgRNA CRISPR Lentivector (Human) (Target 3)

K1416104 ABM 1.0 ug DNA 184.8 EUR

Human NEIL3/ Endonuclease 8-like 3 ELISA Kit

E1730Hu Sunlong 1 Kit 515 EUR
Description: DNA glycosylase FPG2,DNA glycosylase/AP lyase Neil3,Endonuclease VIII-like 3,Nei-like protein 3

Human NEIL3 / Endonuclease 8-like 3 ELISA Kit

E4282h EIAab 96T 736 EUR

Recombinant Human Endonuclease 8-like 3 (NEIL3)

MBS1313224-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1460 EUR

Recombinant Human Endonuclease 8-like 3 (NEIL3)

MBS1313224-002mgEColi MyBiosource 0.02mg(E-Coli) 1160 EUR

Recombinant Human Endonuclease 8-like 3 (NEIL3)

MBS1313224-002mgYeast MyBiosource 0.02mg(Yeast) 1220 EUR

Recombinant Human Endonuclease 8-like 3 (NEIL3)

MBS1313224-01mgEColi MyBiosource 0.1mg(E-Coli) 1395 EUR

Recombinant Human Endonuclease 8-like 3 (NEIL3)

MBS1313224-01mgYeast MyBiosource 0.1mg(Yeast) 1435 EUR

Lenti ORF particles, NEIL3 (mGFP-tagged) - Human nei endonuclease VIII-like 3 (E. coli) (NEIL3), 200ul, >10^7 TU/mL

RC206838L2V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF particles, NEIL3 (mGFP-tagged) - Human nei endonuclease VIII-like 3 (E. coli) (NEIL3), 200ul, >10^7 TU/mL

RC206838L4V Origene Technologies GmbH 200 µl Ask for price

Human Endonuclease 8- like 3, NEIL3 ELISA KIT

ELI-45663h Nova Lifetech 96tests 696 EUR

Nei Endonuclease VIII Like Protein 3 (NEIL3) Polyclonal Antibody

CAU21269-100ul Biomatik Corporation 100ul 265.9 EUR

Nei Endonuclease VIII Like Protein 3 (NEIL3) Polyclonal Antibody

CAU21269-200ul Biomatik Corporation 200ul 332.6 EUR

Recombinant Human NEIL3 Protein, His (Fc)-Avi-tagged

NEIL3-3609H Creative BioMart 50ug 2398.4 EUR
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Human Endonuclease 8-like 3 (NEIL3) ELISA Kit

RK11648 Abclonal 96T 280 EUR

Human Endonuclease 8-like 3, NEIL3 ELISA Kit

MBS9341634-10x96StripWells MyBiosource 10x96-Strip-Wells 6725 EUR

Human Endonuclease 8-like 3, NEIL3 ELISA Kit

MBS9341634-48StripWells MyBiosource 48-Strip-Wells 550 EUR

Human Endonuclease 8-like 3, NEIL3 ELISA Kit

MBS9341634-5x96StripWells MyBiosource 5x96-Strip-Wells 3420 EUR

Human Endonuclease 8-like 3, NEIL3 ELISA Kit

MBS9341634-96StripWells MyBiosource 96-Strip-Wells 765 EUR

Lenti ORF particles, NEIL3 (Myc-DDK tagged) - Human nei endonuclease VIII-like 3 (E. coli) (NEIL3), 200ul, >10^7 TU/mL

RC206838L1V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF particles, NEIL3 (Myc-DDK tagged) - Human nei endonuclease VIII-like 3 (E. coli) (NEIL3), 200ul, >10^7 TU/mL

RC206838L3V Origene Technologies GmbH 200 µl Ask for price

Neil3 (GFP-tagged) - Mouse nei like 3 (E. coli) (Neil3)

MG209359 Origene Technologies GmbH 10 µg Ask for price

Neil3 (untagged) - Mouse nei like 3 (E. coli) (Neil3), (10ug)

MC206012 Origene Technologies GmbH 10 µg Ask for price

NEIL3 Rabbit pAb

A6819 Abclonal 1000μL 70.85 EUR

NEIL3 siRNA (Mouse)

MBS8227515-15nmol MyBiosource 15nmol 405 EUR

NEIL3 siRNA (Mouse)

MBS8227515-30nmol MyBiosource 30nmol 565 EUR
Our work deciphers repeat-variable diresidues for 5-methylcytosine and 5-hydroxymethylcytosine, and offers instruments for TALE-dependent epigenome recognition.Transcription activator-like effector proteins recognise particular DNA sequences by way of tandem repeats. Here the authors show TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.

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